The first drug, which contains active ingredient – sildenafil, was famous Viagra. In principle, today this drug is produced, but the cost for original pill is 2 – 4 times higher than its generic. All pills containing active ingredient – sildenafil are essentially generic Viagra.
Let Canadian Pharmacy Mall consider its generic characteristics and their differences from the original drug. In original drug creation pharmaceutical company identifies a specific chemical substance, and explores its properties. Tests have been conducted, during which this chemical compound has the most expressed positive and minimum negative effects manifestation. Then, method and industrial technology for active substance production were developed.
Also, at the same time efforts are taken to develop purification from chemical impurities methods that often cause allergic reactions and other serious side effects emergence. After all these steps completed company-developer releases this drug into the market. This is original product, which is patented.
But the validity of medication patent is limited, and usually lasts from 5 to 10 years. After patent expiration, any other pharmaceutical company may use original drug trials and create its own medicine according to specified dosage. You may create your own name for medication, and drug entering the market with exactly the same active substance, but it is much cheaper. Such a medication is known as generics. At the same time, generics may be different from the composition of additive components from original drug.
The only similarity of generics with an original drug is the active substance and its dosage. Very often their production is carried out by active substances creation in chemical laboratories, which are not subjected to serious and thorough clean of impurities.
A large number of impurities that pharmacists call when speaking about any drug which is rather “messy”. Thus, Viagra for the past time period there created a large number of generics, whose names are listed in the section above. All of them belong to sildenafil group.
These pills take just chewing or dissolving because they do not necessarily need to be washed. Moreover, there are various kinds of sildenafil in the form of jelly with different flavors. Jelly Sildenafil pills absorb very softly and quickly and begin to perform much earlier than classic generic Viagra.
In general, worldwide nowadays Sildenafil implies precisely Viagra, which has already become a household name. Therefore, in describing medicines’ properties Sildenafil means all Viagra pills types and its generics as well.
Sildenafil in Products
Sildenafil does not contain in food. Sildenafil is a synthetic chemical substance that is produced using a special technological process.
Moreover, it is rather difficult to obtain it, you cannot carry out chemical reactions in your own kitchen. However, men who want to find a natural substitute for sildenafil may apply foods that are considered to be aphrodisiacs. Aphrodisiacs traditionally include any animal products or plant origin, which have the ability to increase potency and improve sexual function.
Today aphrodisiacs are the following products:
- olive oil;
- pine nuts;
The composition of an active substance includes salt – sildenafil citrate. The active ingredient dosage is different – there pill containing Sildenafil 25 mg, 50 mg and 100 mg. Additive components are:
- titanium dioxide;
- indigo carmine.
Sildenafil is sold in packs of 1, 2, 4, 8 or 12 pills. The pill has diamond, lenticular shape and painted in light blue color. Sildenafil action and effects according to therapeutic mechanism of action related to inhibitors of an enzyme named phosphodiesterase cGMP-specific 5 type or abbreviated PDE5.
And according to the clinical sildenafil effect, it is a vasodilator. These pills eliminate erectile dysfunction in form of inability to achieve or maintain a good erection suitable for complete sexual intercourse. Thus, this drug normalizes physiological response to male sexual excitement.
However, the drug to act, it is necessary to carry out sexual stimulation for a man to reach sexual excitement. Sildenafil helps normalize erection due to its impact on the natural enzymes involved in sexual excitement implementation, ie the adaptation of penis in erection.
During sexual excitement, a large amount of nitric oxide is released, which expands blood vessels and increases blood flow to cavernous bodies of the penis. But nitric oxide performs on blood vessels not independently, but through activation of the second messenger called cGMP (cyclic guanosine monophosphate). And Sildenafil or Viagra inhibits the activity of an enzyme that breaks down cGMP molecule.
Thus, the effect of the secondary agent is extended vessels are widened for longer, and erection is stable. Sildenafil is not able to independently cause blood flow to cavernous bodies of the penis, and bring it into an erected state. This drug is only heightened sexual excitement, which is characterized by the release of certain biologically active substances in the blood flow.
That is, Sildenafil is able to strengthen and extend arisen natural sexual excitement. In the absence of sexual stimulation, any medication including Viagra from Canadian Pharmacy is absolutely useless. However PDE5 enzyme, which breaks down cGMP, is contained not only in penile tissues but also in lung vessels. Therefore Sildenafil is able to expand pulmonary vessels and thus reduce pulmonary pressure.
Moreover, people suffering from pulmonary hypertension, sildenafil relaxes pulmonary vessels, to a lesser extent acting on arteries and veins of other organs and tissues. The use of sildenafil for pulmonary hypertension treatment can improve quality of life, reduce shortness of breath and lower respiratory insufficiency at least for one functional class.
In addition, sildenafil slightly reduces overall blood pressure, but this phenomenon is transient. After drug effect completion blood pressure returned to normal condition.