Usually, the action of this PDE5 inhibitor starts within 30 to 60 minutes. It is a highly potent drug. Studies have revealed the onset of action of the drug to begin as early as 16 minutes. The usual dose taken is in between 25-100mg dose. Its volume of distribution is around 105 liters and protein binding capacity ranges from 94-98%. Eating fatty food before taking the drug delays its action 25 – 45 minutes and it should be kept in mind by the user although consumption has altogether no effect.
After reaching the bloodstream the drug is readily absorbed in the Git tract and produces its action for about 2-4 hrs giving sufficient time to the user before it is degraded and metabolized.
Pde5 inhibitor viagra undergoes metabolism through cytochrome p450 a hepatic isoenzyme. The metabolite mainly produced is N-desmethyl which shows pde5 activity.
The drug affected by the body mainly throws feces and in very low amount through urine. The metabolite formation takes place after 4-5 hours of the dose.
The success of the inhibitors is due to their molecular and structural similarity which helps in pde5 inhibition. Through various clinical trials done, it has been found that pde5 inhibitors have significantly increased the erectile functioning of the penis with respect to placebo.
The success of performing sexual intercourse increased to above 25% mark for users within 16 minutes and 59% for users under 30 minutes. It has also been seen that the drug successfully showed its effect in 65-78% of it’s all users.
It has also been seen through government based surveys that pde5 inhibitors can be even successful in treating Erectile dysfunction cases who also are suffering from other diseases like diabetes, stable heart condition after myocardial infarction, erectile dysfunction due to spinal cord injuries and stable blood pressure patients.
This shows that pde5 inhibitors viagra is the reply from the pharmaceutical companies to erectile dysfunction which is easily available at affordable price. So now you don’t have to be scared and lose hope of having any family because your solution lies at the very next medical store near you.