Pde5 Inhibitors Viagra: A Potent Drug in Treating Erectile Dysfunction

Looking at the title the question that pops up in one’s mind – what erectile dysfunction is? Well erectile dysfunction can be simply explained as the condition in which there’s person’s inability to erect or to maintain the erection during sexual intercourse. This condition is quite common in men from United States and Europe. According to various studies and findings done by various foundations it was reported that almost 20% males above the age of 20 in US suffer from ED and it is mostly seen in the age group of 40-70, and 75% men above 70 years can’t even have an erection. It can be said that ED is associated with a person’s age.

This raises another question what is the cure for ED?, The answer is simple pde5 inhibitors viagra or Sildenafil. The drug was legalized in the year 1998 and its other variants in the year 2003 before this due to less knowledge in- vitro or implants were the only methods available for treatment of ED Although it is not recommended to use for people with heart condition, low blood pressure, prescribed with nitrates or angina. An estimate shows that over 20 million people were treated after the introduction of this drug. It’s a clear and simple solution to the sexual problems of men.

Understanding it’s Action

Erection of penis occurs when sexual arousal takes place in a person and this leeds to release of nitrous oxide in the body which causes vasodilation of the blood vessels of the corpus cavernosum layer. This in turn results in the accumulation of c-gmp(cyclic gmp) which itself gets metabolized and is responsible for the duration of erection. pde5 is the enzyme responsible for the breakdown of cyclic gmp and thus preventing anymore erection. Pde5 inhibitors viagra selectively and competitively block this enzyme which prevents the hydrolysis of cyclic guanosine monophosphate and thus elongate the function of nitrous oxide. The inhibitors do not inhibit the action directly, therefore are to be taken when there is sexual arousal.

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Time of Action and Duration

Usually the action of pde5 inhibitors viagra starts within 30 to 60 minutes. It is a highly potent drug. Studies have revealed the onset of action of the drug to begin as early as 16 minutes. The usual dose taken is in between 25-100mg dose. Its volume of distribution is around 105 liters and protein binding capacity ranges from 94-98%. Eating fatty food before taking the drug delays its action 25 – 45 minutes and it should be kept in mind by the user although consumption has altogether no effect.

After reaching the blood stream the drug is readily absorbed in the Git tract and produces its action for about 2-4 hrs giving sufficient time to the user before it is degraded and metabolized.

Metabolism, Efficacy and Success Rate

Pde5 inhibitor viagra undergoes metabolism through cytochrome p450 an hepatic isoenzyme. The metabolite mainly produced is N-desmethyl which shows pde5 activity.
The drug affected from the body mainly throws feces and in very low amount through urine. The metabolite formation takes place after 4-5 hours of the dose.
The success of the inhibitors is due to their molecular and structural similarity which helps in pde5 inhibition. Through various clinical trials done it has been found that pde5 inhibitors have significantly increased the erectile functioning of the penis with respect to placebo.

The success of performing sexual intercourse increased to above 25% mark for users within 16 minutes and 59% for users under 30 minutes. It has also been seen that the drug successfully showed its effect in 65-78% of it’s all users.

It has also been seen through government based surveys that pde5 inhibitors can be even successful in treating Erectile dysfunction cases who also are suffering from other diseases like diabetes, stable heart condition after Myocardial infarction, erectile dysfunction due to spinal cord injuries and stable blood pressure patients. All this is measured through profiling under SEP (Sexual Encounter Profile), IIEF-EF(International Index of Erectile Function – Erectile Function Domain) and GAQ(Global Assessment Question).

This shows that pde5 inhibitors viagra is the reply from the pharmaceutical companies to erectile dysfunction which is easily available at affordable price. So now you don’t have to be scared and lose hope of having any family because your solution lies at the very next medical store near you.

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