Instruction for Canadian Viagra Online

Viagra Description

  • The active substance: Sildenafil Citrate.
  • Administration: The drug is used to improve erectile function and is applied at erectile dysfunction treatment.
  • Viagra Pills: coated light blue, diamond-shaped, slightly convex pills with cut and round edges.
  • Viagra is released in 25, 50 and 100 pills.
  • Viagra composition is cellulose, magnesium stearate, calcium hydrogen phosphate anhydrous, croscarmellose sodium.

Canadian Pharmacy Viagra Dosage and Instruction for Use

Taken orally half an hour before sexual intercourse. Viagra daily recommended dose is 100 mg but it can be correspondingly reduced to 50 and 25 mg considering individual medication tolerance. The daily dose of 100 mg should be taken no more than once a day.

Viagra Action

Canada Pharmacy Mall Viagra is proven and most convenient drug for erectile dysfunction treatment. This medication is selective inhibitor of specific phosphodiesterase cGMF 5 (PDE5).

Viagra performs with sexual stimulation presence only. Viagra online does not contribute to visual loss syndrome and has no effect on intraocular pressure as well as on pupil size.

Sildenafil has no direct relaxing effect on isolated corpus cavernosum, but enhances relaxing effect of nitric oxide – NO on this tissue by inhibiting PDE5, which is responsible for cGMP degradation in cavernous body.

PDE5 inhibition by sildenafil influence results in increased cGMP level in cavernous body, resulting in smooth muscle relaxation and increased blood flow to cavernous body.

In some patients, 1 hour after drug administration at a dose of 100 mg using Farnsworth-Munsell 100 showed mild and transient impaired ability to distinguish between color shades (blue / green); 2 hours after receiving these changes disappear.

It is believed that color vision violation is caused by PDE6 inhibition, which is involved in transmission of light in retina. Canadian Viagra has no effect on visual acuity, contrast perception, electroretinogram, intraocular pressure and pupil diameter.

Viagra

Sildenafil Pharmacokinetics

Pharmacokinetics of Generic Viagra (Sildenafil Citrate) depends on the dose from 25 mg to 100 mg per day.

Absorption Into Blood

Sildenafil is fairly rapidly absorbed. After receiving 100 mg of sildenafil limiting concentration of drug in the blood is 18 ng / ml (38nM), while taking the drug without food it is absorbed within half an hour to two hours min (1 hour on average).

At fatty foods use, the intake of sildenafil in blood is increased by about half an hour, and maximum concentration in blood is reduced by 29%

Distribution

Sildenafil and its major component in approximately 96% is bound with plasma proteins. Sildenafil concentration has no effect on protein binding. 105 liters – Vd sildenafil at steady state, indicating that its distribution into tissues.

When receiving 100 mg of sildenafil, a half hour after administration were detected 0.0002% (average 188 ng) in the sperm preparation.

Metabolism

  • Basically Sildenafil Citrate online is metabolized under the influence of CYP3A4 (major route) and CYP2C9 (minor route) of hepatic microsomal isoenzymes.
  • By productivity action on PDE metabolite is comparable with sildenafil and its activity against PDE5 in vitro is approximately 50% of sildenafil performance.
  • The concentration of metabolite in plasma is approximately 40% of that of sildenafil.

Breeding

The total clearance of sildenafil from the body is 41 l / h, T1 / 2 Baths. phase – 3-5 hours after oral or / in the introduction of generic Viagra comes in form of metabolites in feces of 80% of dose in urine about 13% of dose.

Viagra Canada Pharmacy Indications

Erectile dysfunction is inability to achieve or maintain erection necessary for normal sexual intercourse.

Viagra Canada Pharmacy performs only if there is sexual stimulation. Viagra online is not intended for use in women, but there is a special drug Pink Female Viagra for women.

Generic Viagra Dosage

  1. The drug is taken orally.
  2. Usual initial dose is 50 mg for 1 hour before intercourse. Given the lack of effect and side effects, the dosage can be increased to 100 mg or decreased to 25 mg.
  3. Take no more than 1 time per day. For elderly men dose adjustment is required.
  4. In severe renal insufficiency (creatinine clearance).
  5. When liver pathologies Canadian Viagra dosage can be reduced to 25 mg.
  6. When combined with ritonavir, the maximum single dose of sildenafil should be 25 mg, no more than 1 time in 48 hours.
  7. In a joint application with inhibitors of CYP3A4 isoenzyme (such as erythromycin, saquinavir, ketoconazole, itraconazole), initial dose should be 25 mg.
  8. To minimize the risk of postural hypotension in patients taking alpha blockers, Sildenafil should be taken only after hemodynamic stabilization which is achieved in these patients. Feasibility of reducing starting dose of sildenafil should be considered.

Side Effects Caused by Viagra

Side effects are usually mild or or absent. The frequency of adverse events is increased with dose.

The most common side effects:

  • Nervous system: headache (10.8%);
  • Cardiovascular system: vasodilation (flushing) (10.9%).

Common Side Effects:

  • dizziness (2.9%);
  • Nervous system: authority of changes in vision (blurred vision, changes in sensitivity to light) (2.5%).

Digestive System:

  • dyspepsia (3.0%);
  • hromatopsiya (mild and transient, mostly change perception of color shades)(1.1%);
  • Cardiovascular palpitations (1.0%);
  • Respiratory rhinitis (nasal congestion) (2.1%).

In case of Canada Viagra overdose likelihood of side effects is increased:

  • Immune System: hypersensitivity reactions (including rash);
  • Cardiovascular system: tachycardia, decreased blood pressure, fainting, nosebleeds;
  • Digestive system: vomiting;
  • Bodies: eye pain, eye redness / scleral injection;
  • Reproductive system: prolonged erection and / or priapism.

Contraindications to Viagra Use

Hypersensitivity and components intolerance.

The drug is contraindicated in men who take donator of nitric oxide, nitrates in any form as sildenafil enhances the hypotensive effect of nitrates.

You should not take Generic Viagra (Sildenafil Citrate) in the following diseases:

  • anatomical penile deformity;
  • cavernous fibrosis;
  • angulation;
  • Peyronie’s disease.

In diseases, possessing priapism development:

  • drepanocytemia;
  • multiple myeloma;
  • leukosis;
  • thrombocytopenia.

Other contraindications:

  • diseases accompanied by bleeding;
  • aggravation of gastric ulcer and duodenal ulcer;
  • retinitis pigmentosa;
  • heart failure;
  • unstable angina;
  • transferred in the last 6 months, myocardial infarction or blood stroke;
  • severe arrhythmia;
  • hypertension.

Information for Patients

Canadian Health and Care Mall recommends you to determine erectile dysfunction causes and determine correct treatment, it is necessary to consult a doctor.

Sexual contact is not recommended for men with:

  • heart disease;
  • unstable angina;
  • myocardial infarction or stroke;
  • arrhythmia;
  • hypertension;
  • hypotension.

Additional Information about Canadian Viagra Online

Widely known remedy for impotence – Canadian Pharmacy Viagra – is fanned by the mass myths. Fiction is often difficult to be distinguished from reality, if you do not have information about this popular drugs.
The first thing to know about Generic Viagra is that this drug is not an aphrodisiac. Viagra generic online does not increase sexual desire, but only helps to improve erection during sexual stimulation. Funds from dull, unattractive partner yet, unfortunately, did not come up.

Viagra works by dilating blood vessels in body, causing heart, lungs and other organs receive more blood. Moreover, Viagra relaxes spasms of smooth muscles in the penis. About 70% of men taking Viagra reported about improved erection.

The drug provides effect within 30 minutes after administration, and its effect lasted for about five hours. Blue pills are advised to take at least an hour before anticipated sexual intercourse.

Nearly half pills of Viagra sold on the internet – a fake but not at Canadian HealthCare Mall: canadianhealthncaremall.com. Experts from London University found that in half of drugs sold online, other substances contain, or at least active ingredients of this Viagra.

Viagra has serious competitors. In 1998, when the drug first appeared on pharmaceutical market, it was the only one of its kind. Now it has two competitors. The drug called Levitra, for example, begins to perform after 16 minutes, working for six hours. In addition, it has possible fewer side effects.

Viagra has side effects! Basically, it’s headaches, hot flushes, dizziness, heart palpitations, indigestion, or blurred vision. When used with other drugs, such as nitrates, Viagra can have severe predispositions.

Canadian Viagra online was discovered accidentally by researchers from pharmaceutical company Pfizer in Kentucky, US state laboratory. In the late 80-ies, scientists have developed a new means from angina when they noticed a strange side effect of drug study, causing an erection in volunteers. The effect was so great that even after completion of experiments, participants demanded the continuation of treatment. They refused to return medications as a result Viagra has gained great popularity worldwide.

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